Dr. Spyropoulos has completed his postgraduate studies in 1979 and he awarded the Ph.D. degree in Computer Studies from Loughborough University of Technology, in England. At that University in 1975 he got his M.Sc. degree in Computing with Applications, while he awarded his BSc in Applied Mathematics from University of Ioannina, Greece in 1974.
From Nov. 1979 till Aug. 1984, after completing his military service, he worked as a S/W Engineer Consultant at the R&D Depts of Greek Air Forces and Army, for the Command & Control Information Systems (CCIS) project. In Sept. 1984 he joined the Artificial Intelligence team at the Department of Computers of Nuclear Research Center "Demokritos" that after 1985 has transformed to the National Centre for Scientific Research (NCSR) "Demokritos".
In 1989 Dr Spyropoulos founded the Software and Knowledge Engineering Laboratory (SKEL) that has become the AI Lab of the Institute. From June 2004 till July 2013 he was elected and appointed as the Director of the Institute of Informatics and Telecommunications. From January 2009 till April 2011 he served as Vice President of the Board of Directors at NCSR "Demokritos" and from May 2010 till March 2011 he also served as acting Director and President of NCSR "Demokritos" in parallel with his duties as Institute director. He is also co-founder of the spin-off company called 'i-sieve' that is formed (Aug. 2004) to explore the 'on-line content analysis technology' developed at the SKEL laboratory. Since 2019 he is an Emeritus Researcher at IIT of NCSR "Demokritos".
At the beginning of his carrier at NCSR "Demokritos" he was involved in research and development for knowledge representation, temporal reasoning, planning and scheduling, and expert systems as well as in software internationalization and localisation, while later he gave emphasis to the problem of information overloading and management of Big Data using NLP for content based categorization, filtering and information extraction from plain texts, or web pages, ontologies, as well as user modeling and exploitation of machine learning methods. This research has been tested in developing operational prototypes for museums, news, industry, naval and or exploration industry, resource management in hospitals, transport and emergency operations, medical diagnosis, parental support, web applications and natural dialogue interactivity among others.
Dr. Spyropoulos has published more than 150 editorials, papers in scientific journals, books, or conferences as well as more than 100 reports (technical, internal or feasibility study reports). His publications has been cited more than 5000 times by third party authors. He coordinated or participated as principal investigator in many European and National R&D as well as Network of Excellence projects with a total budget of more than 12 million Euros. Also, he organised or participated as Chair or Program Committee member respectively, in more than 40 National and International Conferences, Symposiums, Workshops, Seminars and Summer Schools. For many years he serves as member of the Editorial Board of the AI in Medicine (AIIM) journal, and has been an editor in special issues of scientific journals as well as in conferences and workshop proceedings. Since 2002 Dr. Spyropoulos is a Fellow member of the ECCAI (European Coordination Committee of Artificial Intelligence) and a founder member of the Hellenic AI society (EETN) in 1986 servicing for many years as President of the society.